Lifetime stressful experiences and cognitive performance in African American and white older adults: New evidence from a population‐based cohort

BackgroundGrowing evidence suggests that modifiable sociocontextual factors powerfully shape health including risk for Alzheimer’s disease and related dementias (ADRD), and contribute substantially to well‐established racial disparities in cognitive aging. Stressful experiences cluster and accumulate across the lifespan, plausibly impacting brain health, but cognitive effects of lifetime adversity across diverse populations remain underexplored. We examined relationships between lifetime stressful events and cognition among African American and White older adults in the Health and Retirement Study (HRS).MethodThe study sample included non‐demented adults (N=8,222) aged 60 and older who provided cognitive and lifetime stress data at the 2006/08 and 2010/12 HRS waves. Cognitive outcomes included performance on a test of global cognition (Telephone Interview for Cognitive Status) and its immediate and delayed recall subscales. The key predictor of interest was a Lifetime Stress index score (sample range=0‐11 experiences). Mixed‐effects regression models assessed associations of lifetime stress with each cognitive outcome. Polynomial and three‐way interaction models explored potential (1) non‐linear associations between stress and cognition, and (2) moderation of those relationships by race.ResultAfrican Americans (N=1,015) were younger (M=71.7, SD=6.8) than whites (M=72.2, SD=6.3) and reported fewer years of education (p<0.001). Reported number of stressful life events reported (M=1.61, SD=1.45) did not vary by race. In adjusted models (Table 1, Model 2), a significant stress quadratic revealed that relationships with global cognition (p