The dissipation flux coefficient, a measure of the mixing efficiency of a turbulent flow, was computed from microstructure measurements collected with a vertical microstructure profiler in the Sicily Channel. This hotspot for turbulence is characterised by strong shear in the transitional waters between the south-eastward surface flow and the north-westward deep flow. Observations from the two deep passages in the channel showed a contrast in turbulent kinetic energy dissipation rates, with higher dissipation rates at the location with the strongest deep currents. This study investigated the dissipation flux coefficient variability in the context of mechanically driven turbulence with a large range of turbulence intensities. The dissipation...