International audienceBackground: Patients with hematologic malignancies require prophylactic or curative platelet transfusions to prevent or treat bleeding. Treatments such as chemotherapy, radiotherapy, and hematopoietic stem cell transplantation cause persistent thrombocytopenia, necessitating platelet transfusions. However, class I HLA antibodies can cause a serious complication: immune-mediated platelet refractoriness. The mechanisms of alloimmunization are incompletely understood. We explored the immunogenicity of HLA molecules and the phenotype of the HLA-specific CD4+ T cells involved in alloimmunization.Study design and methods: We investigated the role of HLA molecules in platelet transfusion immunogenicity in a retrospective coho...
International audienceBackground: Recent reports have indicated that the risk of anti-D alloimmuniza...
Recently, Jackman et al., have published a very interesting paper entitled ‘Low-level HLA antibodies...
Transfusion plays an important role in the management of patients with hematological malignancies a...
International audienceBackground: Patients with hematologic malignancies require prophylactic or cur...
BACKGROUND: Platelet transfusions can induce alloimmunization against HLA antigens. The use of patho...
Background and objectives: Antibodies (Ab) against HLA and HPA antigens play an important role in HC...
International audienceBackground: Platelet (PLT) transfusions are an essential treatment for bleedin...
Substitution of transfused platelet concentrates are often accused to cause HLA-antibody development...
BACKGROUND: Understanding the cause for platelet refractoriness in a given patient is the critical s...
Despite significant advancements in the production of platelet products, storage, and transfusion, t...
The effectiveness of platelet transfusions, an essential supportive care for mostly hemato-oncologic...
• High, but not low to moderate, HLA antibody levels are associated with platelet refractoriness. In...
International audienceBACKGROUND: Platelet transfusion is aimed at increasing platelet counts to pre...
International audiencePlatelet refractoriness is a serious complication for patients receiving recur...
Background: The formation of alloantibodies directed against class I human leukocyte antigens (HLA) ...
International audienceBackground: Recent reports have indicated that the risk of anti-D alloimmuniza...
Recently, Jackman et al., have published a very interesting paper entitled ‘Low-level HLA antibodies...
Transfusion plays an important role in the management of patients with hematological malignancies a...
International audienceBackground: Patients with hematologic malignancies require prophylactic or cur...
BACKGROUND: Platelet transfusions can induce alloimmunization against HLA antigens. The use of patho...
Background and objectives: Antibodies (Ab) against HLA and HPA antigens play an important role in HC...
International audienceBackground: Platelet (PLT) transfusions are an essential treatment for bleedin...
Substitution of transfused platelet concentrates are often accused to cause HLA-antibody development...
BACKGROUND: Understanding the cause for platelet refractoriness in a given patient is the critical s...
Despite significant advancements in the production of platelet products, storage, and transfusion, t...
The effectiveness of platelet transfusions, an essential supportive care for mostly hemato-oncologic...
• High, but not low to moderate, HLA antibody levels are associated with platelet refractoriness. In...
International audienceBACKGROUND: Platelet transfusion is aimed at increasing platelet counts to pre...
International audiencePlatelet refractoriness is a serious complication for patients receiving recur...
Background: The formation of alloantibodies directed against class I human leukocyte antigens (HLA) ...
International audienceBackground: Recent reports have indicated that the risk of anti-D alloimmuniza...
Recently, Jackman et al., have published a very interesting paper entitled ‘Low-level HLA antibodies...
Transfusion plays an important role in the management of patients with hematological malignancies a...