Clarification of Definitions of Hyperprogressive Disease During Immunotherapy for Non–Small Cell Lung Cancer

International audienceQuestion: Are the different definitions used to assess HPD representative of a same tumoral behaviour? Findings: For this multicentre cohort study including 406 patients with advanced NSCLC treated with PD-1/PD-L1 inhibitors, the different definitions resulted in diverse incidences, patients' characteristics and correlations with survival outcomes. Meaning: The 5 definitions are not representative of a same tumoral behaviour. We defined a new criteria ΔTGR > 100 that looks more accurate assessing HPD