Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic environment. Our analysis reveals that long-term adaptation to high altitude enables healthy individuals to maintain their iron stores within the physiological range despite elevated requirements for erythropoiesis. However, in vulnerable populations with increased iron demand (e.g., pregnant women or exercising individuals), iron stores are less likely to be replenished quickly when living at high altitude. Future studies need to address whether...
Is increased hematopoiesis needed at altitude? The increased hemoglobin concentration in high-altitu...
Background: Because the pathogenesis of high altitude polycythemia (HAPC) is unclear, the aim of the...
Antecedentes. La investigación sobre los efectos de la exposición a la altura sobre la eritropoyesis...
Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most importan...
With ascent to high altitude, the reduction in the partial pressure of oxygen (PO₂) drives the stabi...
Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and sign...
It is classically thought that increases in hemoglobin mass (Hbmass) take several weeks to develop u...
Increasing the hemoglobin (Hb) concentration is a major mechanism adjusting arterial oxygen content ...
<div><p>It is classically thought that increases in hemoglobin mass (Hbmass) take several weeks to d...
Decreased oxygen availability at high altitude requires physiological adjustments allowing for adequ...
Iron is tightly connected to oxygen ho-meostasis and erythropoiesis. Our aim was to better understan...
High-altitude (HA) exposure may stimulate significant physiological and molecular changes, resulting...
To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hbmas...
Synopsis Research on humans at high-altitudes contributes to understanding the processes of human ad...
Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding ...
Is increased hematopoiesis needed at altitude? The increased hemoglobin concentration in high-altitu...
Background: Because the pathogenesis of high altitude polycythemia (HAPC) is unclear, the aim of the...
Antecedentes. La investigación sobre los efectos de la exposición a la altura sobre la eritropoyesis...
Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most importan...
With ascent to high altitude, the reduction in the partial pressure of oxygen (PO₂) drives the stabi...
Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and sign...
It is classically thought that increases in hemoglobin mass (Hbmass) take several weeks to develop u...
Increasing the hemoglobin (Hb) concentration is a major mechanism adjusting arterial oxygen content ...
<div><p>It is classically thought that increases in hemoglobin mass (Hbmass) take several weeks to d...
Decreased oxygen availability at high altitude requires physiological adjustments allowing for adequ...
Iron is tightly connected to oxygen ho-meostasis and erythropoiesis. Our aim was to better understan...
High-altitude (HA) exposure may stimulate significant physiological and molecular changes, resulting...
To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hbmas...
Synopsis Research on humans at high-altitudes contributes to understanding the processes of human ad...
Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding ...
Is increased hematopoiesis needed at altitude? The increased hemoglobin concentration in high-altitu...
Background: Because the pathogenesis of high altitude polycythemia (HAPC) is unclear, the aim of the...
Antecedentes. La investigación sobre los efectos de la exposición a la altura sobre la eritropoyesis...