Overcoming the challenges of phage therapy for industrial aquaculture: A review

Aquaculture is the fastest-growing sector in food industry. Its development is powered by the intensification ofthe production which increased bacterial disease occurrence and spreading. As aquaculture deeply relies on amassive prophylactic and therapeutic use of antibiotics, it is threatened by the emergence of multi drug resistantbacteria. The stalled development of new antibiotics makes finding new therapeutic solutions a burning issue.Thanks to their specific host range, their ability to treat both the farmed species and the environment, theirlimited ecological impact and their abundance in the environment, bacteriophages represent a promising sustainablesolution to control pathogenic aquaculture bacteria.In this review we discuss the interest of phage biocontrol for aquaculture and how can bacterial resistance,ecological, pharmacological and production related issues be solved