International audienceToll-like receptors (TLRs) on host cells are chronically engaged by microbial ligands during homeostatic conditions. These signals do not cause inflammatory immune responses in unperturbed mice, even though they drive innate and adaptive immune responses when combating microbial infections. A20 is a ubiquitin-modifying enzyme that restricts exogenous TLR-induced signals. We show that MyD88-dependent TLR signals drive the spontaneous T cell and myeloid cell activation, cachexia, and premature lethality seen in A20-deficient mice. We have used broad spectrum antibiotics to demonstrate that these constitutive TLR signals are driven by commensal intestinal flora. A20 restricts TLR signals by restricting ubiquitylation of t...
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in "danger...
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multipl...
The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes t...
International audienceToll-like receptors (TLRs) on host cells are chronically engaged by microbial ...
BACKGROUND and AIMS: Toll-like receptors (TLR) are innate immune receptors involved in recognition o...
SummaryMuramyl dipeptide (MDP), a product of bacterial cell-wall peptidoglycan, activates innate imm...
SummaryToll-like receptor (TLR)-mediated immune responses are downregulated by several mechanisms th...
Background & Aims: Toll-like receptors (TLR) are innate immune receptors involved in recogniti...
Abstract: TLRs activate immune responses by sensing microbial structures such as bacterial LPS, vira...
International audienceTLR sense microbial infections, and control activation of immune responses. De...
A20 is a zinc finger protein that renders cells resistant to apoptosis. However, the recent demonstr...
The ubiquitin-editing protein A20 (TNFAIP3) is a key player in termination of NF-κB signaling, and t...
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in “danger...
Dendritic cells (DCs), which are known to support immune activation during infection, may also regul...
The recognition of foreign pathogens by innate pattern recognition receptors (PRRs) serves as the fi...
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in "danger...
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multipl...
The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes t...
International audienceToll-like receptors (TLRs) on host cells are chronically engaged by microbial ...
BACKGROUND and AIMS: Toll-like receptors (TLR) are innate immune receptors involved in recognition o...
SummaryMuramyl dipeptide (MDP), a product of bacterial cell-wall peptidoglycan, activates innate imm...
SummaryToll-like receptor (TLR)-mediated immune responses are downregulated by several mechanisms th...
Background & Aims: Toll-like receptors (TLR) are innate immune receptors involved in recogniti...
Abstract: TLRs activate immune responses by sensing microbial structures such as bacterial LPS, vira...
International audienceTLR sense microbial infections, and control activation of immune responses. De...
A20 is a zinc finger protein that renders cells resistant to apoptosis. However, the recent demonstr...
The ubiquitin-editing protein A20 (TNFAIP3) is a key player in termination of NF-κB signaling, and t...
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in “danger...
Dendritic cells (DCs), which are known to support immune activation during infection, may also regul...
The recognition of foreign pathogens by innate pattern recognition receptors (PRRs) serves as the fi...
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in "danger...
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multipl...
The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes t...