National audienceThe widespread emergence of bacterial resistance has led to an urgent need to develop new strategies to regain the efficacy of antibacterials. One of the emerging concept is to target the bacterial membrane bilayer. Aminoglycosides are among the most potent antimicrobials to treat severe infections. In the search for new antibiotics, we have synthesized derivatives of the small aminoglycoside, neamine in the aim to obtain amphiphilic antibiotics able to disturb bacterial membrane bilayer. One to four hydroxyl functions of neamine were capped with phenyl, naphthyl, pyridyl, or quinolyl rings. The 3',4'-, 3',6- and the 3',4',6-2-naphthylmethylene (2NM) derivatives were active against both sensitive and resistant S. aureus str...
Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics disturbing ...
Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct ...
International audienceBacterial membranes are highly organized, containing specific microdomains tha...
National audienceThe widespread emergence of bacterial resistance has led to an urgent need to devel...
Aminoglycosides are among the most potent antimicrobials to eradicate Pseudomonas aeruginosa. Howeve...
International audienceAminoglycosides are among the most potent antimicrobials to eradicate Pseudomo...
Amphiphilic aminoglycoside derivatives are potential new antimicrobial agents mostly developed to fi...
Aminoglycosides are antibiotic drugs that act through binding to rRNA. In the search for antimicrobi...
International audienceThe development of novel antimicrobial agents is urgently required to curb the...
AbstractAminoglycosides are among the most potent antimicrobials to eradicate Pseudomonas aeruginosa...
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused ...
Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics disturbing ...
Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct ...
International audienceBacterial membranes are highly organized, containing specific microdomains tha...
National audienceThe widespread emergence of bacterial resistance has led to an urgent need to devel...
Aminoglycosides are among the most potent antimicrobials to eradicate Pseudomonas aeruginosa. Howeve...
International audienceAminoglycosides are among the most potent antimicrobials to eradicate Pseudomo...
Amphiphilic aminoglycoside derivatives are potential new antimicrobial agents mostly developed to fi...
Aminoglycosides are antibiotic drugs that act through binding to rRNA. In the search for antimicrobi...
International audienceThe development of novel antimicrobial agents is urgently required to curb the...
AbstractAminoglycosides are among the most potent antimicrobials to eradicate Pseudomonas aeruginosa...
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
International audienceThe aminoglycoside antibiotics bind to the 16S bacterial rRNA and disturb the ...
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused ...
Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics disturbing ...
Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct ...
International audienceBacterial membranes are highly organized, containing specific microdomains tha...