Add to ORKGPrimary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained. We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated post-synaptic excitation. Further controlled studies are necessary to confirm this finding
Postural Tachycardia Syndrome (PoTS) represents a disorder of the autonomic nervous system that resu...
AbstractPerampanel (PER) is a novel noncompetitive AMPA-receptor antagonist approved in over 40 coun...
AbstractPerampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-...
Background: Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unkn...
Primary orthostatic tremor (POT) is a rare disorder for which current treatments are largely ineffec...
Background: Primary orthostatic tremor (POT) remains a therapeutic conundrum. Various medication cla...
Primary orthostatic tremor (POT) may be a cause of postural instability in older people. Though unus...
Primary orthostatic tremor (POT) is a rare disorder characterised by an intense sense of unsteadines...
International audienceBackgroundPrimary orthostatic tremor is a rare disorder that is still under-di...
Primary orthostatic tremor (OT) is a rare but disabling condition characterized by leg tremor and fe...
Primary orthostatic tremor is a regular fast lower limb tremor causing unsteadiness on standing. Tre...
Perampanel, a novel, noncompetitive, selective AMPA-receptor antagonist demonstrated evidence of eff...
Perampanel is the first-in-class selective and noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole...
International audienceBackground: Primary orthostatic tremor (POT) is a movement disorder characteri...
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the postsynaptic membrane a...
Postural Tachycardia Syndrome (PoTS) represents a disorder of the autonomic nervous system that resu...
AbstractPerampanel (PER) is a novel noncompetitive AMPA-receptor antagonist approved in over 40 coun...
AbstractPerampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-...
Background: Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unkn...
Primary orthostatic tremor (POT) is a rare disorder for which current treatments are largely ineffec...
Background: Primary orthostatic tremor (POT) remains a therapeutic conundrum. Various medication cla...
Primary orthostatic tremor (POT) may be a cause of postural instability in older people. Though unus...
Primary orthostatic tremor (POT) is a rare disorder characterised by an intense sense of unsteadines...
International audienceBackgroundPrimary orthostatic tremor is a rare disorder that is still under-di...
Primary orthostatic tremor (OT) is a rare but disabling condition characterized by leg tremor and fe...
Primary orthostatic tremor is a regular fast lower limb tremor causing unsteadiness on standing. Tre...
Perampanel, a novel, noncompetitive, selective AMPA-receptor antagonist demonstrated evidence of eff...
Perampanel is the first-in-class selective and noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole...
International audienceBackground: Primary orthostatic tremor (POT) is a movement disorder characteri...
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the postsynaptic membrane a...
Postural Tachycardia Syndrome (PoTS) represents a disorder of the autonomic nervous system that resu...
AbstractPerampanel (PER) is a novel noncompetitive AMPA-receptor antagonist approved in over 40 coun...
AbstractPerampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-...