Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (5’UTR) of transcripts, which can regulate translation of the correspondent main open reading frame (mORF). During endoplasmic reticulum (ER) stress, the accumulation of unfolded proteins activates the ER-resident PKR-like ER kinase (PERK), which results in phosphorylation of eIF2α to inhibit global mRNA translation, while allowing the selective uORF-mediated translation of downstream effectors responsible for stress resolution or, ultimately, cell death. The dual role of PERK in regulating cell fate was implicated in human diseases, like diabetes, neurodegenerative disorders and cancer. Moreover, mutations in the EIF2AK3 gene (encoding PERK) ...
Tauopathies are neurodegenerative diseases characterized by tau protein pathology in the nervous sys...
Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryot...
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157)L. Romão (e...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Genome-wide studies pointed out translation as a major regulator of gene expression, being a key pos...
Many genome-wide studies pointed out translation as a major regulator of gene expression, being a ke...
Objective: PERK is one of the three sensor proteins from the ER that are responsible for inducing th...
Proper response to cellular insults is critical for maintenance of cellular function and viability. ...
© 2019, The Author(s). The UPR (Unfolded Protein Response) is a well-orchestrated response to ER pro...
Endoplasmic reticulum (ER) stress activates an integrated stress response which causes inhibition of...
Abstract: Upstream open reading frames (uORFs) are major gene expression regulatory elements. In man...
poster abstractDisruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER s...
Tauopathies are neurodegenerative diseases characterized by tau protein pathology in the nervous sys...
Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryot...
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157)L. Romão (e...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (...
Genome-wide studies pointed out translation as a major regulator of gene expression, being a key pos...
Many genome-wide studies pointed out translation as a major regulator of gene expression, being a ke...
Objective: PERK is one of the three sensor proteins from the ER that are responsible for inducing th...
Proper response to cellular insults is critical for maintenance of cellular function and viability. ...
© 2019, The Author(s). The UPR (Unfolded Protein Response) is a well-orchestrated response to ER pro...
Endoplasmic reticulum (ER) stress activates an integrated stress response which causes inhibition of...
Abstract: Upstream open reading frames (uORFs) are major gene expression regulatory elements. In man...
poster abstractDisruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER s...
Tauopathies are neurodegenerative diseases characterized by tau protein pathology in the nervous sys...
Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryot...
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157)L. Romão (e...