The role of 1,2,3-triazole as heteroaromatic building block in metal ion coordination

1,4-disupstituirani 1,2,3-triazoli sintetiziraju se bakrom kataliziranom azid alkin cikloadicijom (CuAAC, eng. copper catalysed azide alkine cycloaddition), koja je ujedno i najzastupljenija click reakcija. 1,2,3-triazoli se zbog mogućnosti koordiniranja metalnih iona na svoje heteroatome uspješno primjenjuju u dizajnu i razvoju kemijskih senzora za metalne ione. U ovom je radu prikazan pregled triazolnih fluorescentnih senzora za određivanje Zn(II), Al(III), Fe(III), Hg(II) i Cu(II) iona i fluorescentnih senzora za određivanje Cu(I) i Cu(II) iona temeljenih na benzazolnim derivatima. Također, objašnjeni su mehanizmi stvaranja fluorescentnog signala kao posljedica koordiniranja metalnih iona na senzorsku molekulu, te je predložena sinteza benztiazolnog fluorescentnog senzora za određivanje metalnih iona s triazolnom jedinicom za koordiniranje iona. Predložena višestupnjevita sinteza provedena je eksperimentalno, no benztiazolni derivat 1,2,3-triazola nije uspješno izoliran.Copper catalysed azide alkine cycloadition reaction (CuAAC), one of the most common click reaction, is used for 1,4-disupstitued 1,2,3-triazole synthesis. 1,2,3-triazoles are successfully applied in design and development of chemical sensors for metal ions because of their possibility to coordinate various metal ions. This work gives a preview of fluorescent triazole derived sensors for Zn(II), Al(III), Fe(III), Hg(II) i Cu(II) ions and benzimidazole and benzothiazole sensors for Cu(I) and Cu(II) ions. Also, different metal coordination mechanisms are explained in this work and the synthesis of novel molecular sensor with benzothiazole and 1,2,3-triazole moiety is proposed. The proposed synthesis, composed of multiple steps, was carried out, but the benzothiazole 1,2,3-triazole derivate was not successfully obtained