Haemostatic Profile of Chronic Liver Disease Patients

Introduction: A wide spectrum of hematological disturbances is known to be observed in patients with chronic liver disease.Aims:Present study was planned to monitor the coagulation factors abnormalities during the gradual deterioration of liver disease.Materials and methods: Present study is retrospectively done on 60 patients of chronic liver disease who were enrolled in this study. Biochemical, Haemostatic and coagulation variables were estimated in patients and compared with the baseline levels of healthy subjects.This study was carried out at the department of Pathology, Fathima Medical College, Kadapa, Andhra Pradesh, during the period from April 2018 to November 2020.Results: In total 60 patients serum bilirubin levels were approximately four times average and showed a marked decrease in serum albumin levels. Patients with both serum bilirubin and albumin HCC (group III) levels were significantly affected, similar to the Child C cirrhosis patient pattern. These patients also had elevated ALT and AST, respectively. Platelet count in Child B, C and HCC revealed a significant thrombocytopenia, compared to both normal and child A cirrhotic patients. Compared to normal group, PT was significantly prolonged in patients with Child C and HCC, Compared to patients with Child A, PT was significantly increased only in cirrhotic patients with Child C.In HCC patients had lower plasma fibrinogen compared to all stages of cirrhosis. Plasma calciumwas above the baseline of normal subjects in cirrhotic patients with Childs A and B. Child C and HCC patients, however, showed normal calcium levels.Conclusion: The results indicated that the haemostatic abnormalities in PT, fibrinogen, and calciumwere deteriorated in parallel with the gradual regression of the constitutional function of liver