Combined moxidectin-levamisole treatment against multidrug-resistant gastrointestinal nematodes: A four-year efficacy monitoring in lambs

Luque Sonia
Lloberas, María Mercedes
Cardozo, Patricia Alejandra
Virkel, Guillermo
Farias, Cristina
Viviani, Paula
Lanusse, Carlos Edmundo
Alvarez, L.
Lifschitz, Adrian Luis

Open link

Publication date

January 2021

DOI

10.1016/j.vetpar.2021.109362

Publisher

Elsevier BV

Journal

Veterinary Parasitology

Abstract

Nematicide combinations may be a valid strategy to achieve effective nematode control in the presence of drug resistance. The goal of the current trial was to evaluate the pharmaco-parasitological performance of the moxidectin (MOX) and levamisole (LEV) combination after four years of continuous use in lambs naturally parasitized with multi-resistant gastrointestinal nematodes. At the beginning of the trial, 40 lambs were divided into four groups (n = 10), which were untreated (control) or subcutaneously treated with MOX (0.2 mg/kg), LEV (8 mg/kg) or with the combination MOX + LEV (administered separately at 0.2 and 8 mg/kg, respectively). Blood samples were collected at different times post-treatment and LEV and MOX plasma concentrations w...