Metabolic and molecular effects of edible oils on PPAR modulators in rabbit liver

Background: Peroxisome proliferator-activated receptors are the receptors that switch-on DNA responding elements as heterodimers with nuclear retinoic acid. These are the transcription factors and belong to the family of nuclear receptors and key regulators for lipid and glucose metabolism.Methods: The study was designed to investigate the effect of edible oil on PPAR Alpha & Gamma expression on rabbit liver.Results: Reduced Glutathione (GSH) activity showed a significant increase and glutathione peroxidase (GPx) activity showed a significant decrease in batch II and batch III in comparison to control group was observed. Out of the total 3 batches, an increase was significantly increased in batch III (160%) in comparison to batch II (151%). Inedible oil-treated Batches, PPAR α, and PPAR γ levels were found to decrease significantly for the control batch. The decrease in PPAR alpha levels in batch II and batch III was 1.7 and 2.2 fold with p<0.01. In the case of PPAR gamma, the corresponding values increased by 1.6 and 2.4 fold respectively with p