Calciphylaxis

Calciphylaxis is a rare, often fatal, systemic disorder characterized by deposition (precipitation) of calcium hosphate salts (calcification) in the medial layer of the arteries and soft tissues. Calcification of the media is followed by fibrous hyperplasia of the intima with obliteration of the lumen and tissue ischemia, necrosis, and gangrene. The first description of calciphylaxis was published in 1962. Calciphylaxis occurs in patients with end stage renal disease. Almost all reported patients were on dialysis.Scripta Scientifica Medica 2007;39(1):49-5