Response to the commentary of Vladimír Štrbák

In his Commentary, Vladimír Štrbák raises an interesting point by linking the reported effects of cell shrinking and swelling to the proposed adipocyte-driven model for weight regain. Particularly intriguing is the fact that adipocyte shrinking seems to hamper their glucose uptake by keeping Akt in the dephosphorylated state, whereas adipocyte swelling facilitates glucose uptake.Adipobiology 2011; 3: 19