Evaluation of penicillin G residues by kidney inhibition swab tests in sow body fluids and tissues following intramuscular injection

In 2011, the USDA-Food Safety and Inspection Service (FSIS) changed the method used for screening swine tissues for antimicrobial residues from the Fast Antimicrobial Screen Test to the Kidney Inhibition Swab (KIS™). Here, we describe the use of KIS™ test for the detection of penicillin G residues in kidney, liver, plasma, urine, and skeletal muscle of heavy sows following the administration of a 5x label dose of penicillin G procaine. Such off-label use is legal in the United States under the Animal Medicinal Drug Use Clarification Act (AMDUCA) when label routes or doses are ineffective at treating disease and is commonly used to treat bacterial infections in heavy sows