Add to ORKGWe performed a systematic analysis of blood DNA methylation profiles from 4,483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of blood cell proportions and elevated smoking exposure derived from the DNA methylation data, with the largest differences seen in treatment-resistant schizophrenia patients. We implemented a stringent pipeline to meta-analyze epigenome-wide association study (EWAS) results across datasets, identifying 95 DMPs associated with psychosis and 1,048 DMPs associated with schizophrenia, with evidence of colocalization ...
Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we identified...
Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychi...
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipo...
We performed a systematic analysis of blood DNA methylation profiles from 4,483 participants from se...
Recent studies suggest that genetic and environmental factors do not account for all the schizophren...
Attempts to discover genes that are involved in the pathogenesis of major psychiatric disorders have...
Schizophrenia (SZ) is severe neuropsychiatric disorder with significant costs to the individual and ...
Epigenetic studies present unique opportunities to advance schizophrenia research because they can p...
Schizophrenia is a serious, complex psychiatric illness that affects around 1% of people globally, c...
We thank Dr Hannah Elliott (University of Bristol MRC Integrative Epidemiology Unit) for providing c...
Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at genetic, epi...
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipo...
Research has shown that besides genes and environment, epigenetic factors are also playing a role in...
DNA methylation has been proposed as a potential molecular mechanism linking environmental risk fact...
Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cel...
Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we identified...
Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychi...
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipo...
We performed a systematic analysis of blood DNA methylation profiles from 4,483 participants from se...
Recent studies suggest that genetic and environmental factors do not account for all the schizophren...
Attempts to discover genes that are involved in the pathogenesis of major psychiatric disorders have...
Schizophrenia (SZ) is severe neuropsychiatric disorder with significant costs to the individual and ...
Epigenetic studies present unique opportunities to advance schizophrenia research because they can p...
Schizophrenia is a serious, complex psychiatric illness that affects around 1% of people globally, c...
We thank Dr Hannah Elliott (University of Bristol MRC Integrative Epidemiology Unit) for providing c...
Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at genetic, epi...
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipo...
Research has shown that besides genes and environment, epigenetic factors are also playing a role in...
DNA methylation has been proposed as a potential molecular mechanism linking environmental risk fact...
Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cel...
Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we identified...
Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychi...
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipo...