MRI and Localized Proton Spectroscopy in Human Leg Muscle at 7 Tesla Using Longitudinal Traveling Waves

Using a small resonant loop to produce a longitudinal traveling wave on a human 7-T system allows MR to be performed over the entire volume of the human leg. We have used this capability to perform localized proton MR spectroscopy of the lipid composition of muscle in volunteers with a coil placed similar to 30 cm away from the region of interest. Spectra with a reasonable signal-to-noise ratio can be acquired in a clinically relevant data acquisition time of less than 5 min using the loop in transmit/receive mode, maintaining the full flexibility to acquire spectra from any part of the calf and/or thigh. If a local receive coil is used in combination with the remote transmit coil, then the signal-to-noise improves significantly, as expected. Magn Reson Med 63:297-302, 2010. (C) 2010 Wiley-Liss, Inc.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas