Dystonia in complex regional pain syndrome : clinical, pathophysiological and therapeutic aspects

The clinical characteristics of Complex Regional Pain Syndrome (CRPS) are defined by pain and various combinations of sensory disturbances, autonomic features, and sudomotor and trophic changes. Furthermore, patients with CRPS may suffer from movement disorders, of which dystonia is the most prevalent. Dystonia of CRPS can affect multiple extremities, is often resistant to treatment and seems to have a poor prognosis. Reliable information on the nature, chronology and clinical determinants of dystonia in CRPS patients is lacking but could provide better insight in the underlying pathophysiological mechanism. The results of our studies on clinical and neurophysiologic aspects of patients with multiple CRPS and MDs in CRPS provided data that suggest disturbances at multiple levels of the CNS. Maladaptive neural plasticity likely is an important mechanism underpinning the MDs that may occur in CRPS. The presence of disturbances at multiple levels of the central nervous system parallels recent hypotheses on the underlying mechanisms suggested for other types of dystonia. Finally, the study on intrathecal baclofen administration in patients with CRPS and dystonia showed marked improvement of dystonia and pain scores after one year.Pfizer, Allergan, Nederlandse Vereniging van Posttraumatische dystrofie Patienten, van Alkemade-Keuls-fonds, J.E. Jurriaanse stichting, Ipsen BVUBL - phd migration 201