BACKGROUND Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD. METHODS AND RESULTS Incident cases (n=742), that is, participants who developed CHD during a median follow-up of 12.1 years (range, 0.0-16.9 years), were compared with a randomly selected subcohort of 2221 participants selected from the total cohort (n=21 148). We genotyped 179 SNPs previously associated with CHD or CHD RF in GWAS as published up...
BACKGROUND:Recent GWAS studies have identified more than 300 SNPs associated with variation in blood...
It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can...
Objective: We examined whether a panel of SNPs, systematically selected from genome-wide association...
Background-Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphis...
Background-Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphis...
Objective: Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associat...
SummaryBackgroundComparison of patients with coronary heart disease and controls in genome-wide asso...
Objective: Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associat...
Background Comparison of patients with coronary heart disease and controls in genome-wide associatio...
AIMS: Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of g...
Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of ge...
Aims Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large stud...
Recent studies have evaluated whether incorporating nontraditional risk factors improves coronary he...
Objective: To examine the incremental predictive value of genetic risk scores of coronary heart dise...
BackgroundRecent GWAS studies have identified more than 300 SNPs associated with variation in blood ...
BACKGROUND:Recent GWAS studies have identified more than 300 SNPs associated with variation in blood...
It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can...
Objective: We examined whether a panel of SNPs, systematically selected from genome-wide association...
Background-Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphis...
Background-Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphis...
Objective: Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associat...
SummaryBackgroundComparison of patients with coronary heart disease and controls in genome-wide asso...
Objective: Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associat...
Background Comparison of patients with coronary heart disease and controls in genome-wide associatio...
AIMS: Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of g...
Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of ge...
Aims Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large stud...
Recent studies have evaluated whether incorporating nontraditional risk factors improves coronary he...
Objective: To examine the incremental predictive value of genetic risk scores of coronary heart dise...
BackgroundRecent GWAS studies have identified more than 300 SNPs associated with variation in blood ...
BACKGROUND:Recent GWAS studies have identified more than 300 SNPs associated with variation in blood...
It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can...
Objective: We examined whether a panel of SNPs, systematically selected from genome-wide association...