CD4 T-cells directed against mismatched HLA-DP isolated following donor CD4 T-cell infusion after allogeneic stem cell transplantation show differential tissue recognition

Donor T-cells for hematopoietic-restricted minor histocompatibility antigens are induced in patients with combined Graft-versus-Leukemia and Graft-versus-Host disease

Pont, M.J.
Bergen, C.A.M. van
Honders, M.W.
Luxemburg-Heijs, S.A.P. van
Kester, M.G.D.
Falkenburg, J.H.F.
Griffioen, M.

November 2014

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation.

Milosevic, S.
Bachnick, B.
Karim, K.
Bornkamm, G.W.
Witter, K.
Gerbitz, A.
Mautner, J.
Behrends, U.

January 2010

BACKGROUND: After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells m...

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation

Herr, W.
Eichinger, Y.
Beshay, J.
Bloetz, A.
Vatter, S.
Mirbeth, C.
Distler, E.
Hartwig, U. F.
Thomas, S.

January 2017

Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogen...

CD4(+) T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

Lamers, C.H.J.
Wijers, R.
Bergen, C.A.M. van
Somers, J.A.E.
Braakman, E.
Gratama, J.W.
Debets, R.
Falkenburg, J.H.F.
Cornelissen, J.J.

October 2016

HematologyImmunobiology of allogeneic stem cell transplantation and immunotherapy of hematological d...

Image_1_CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II.TIF

Peter van Balen (4889299)
Cornelis A. M. van Bergen (5657533)
Simone A. P. van Luxemburg-Heijs (6092510)
Wendy de Klerk (6092513)
Esther H. M. van Egmond (6092516)
Sabrina A. J. Veld (3595007)
Constantijn J. M. Halkes (353655)
Jaap-Jan Zwaginga (6092519)
Marieke Griffioen (119817)
Inge Jedema (4889290)
J. H. Frederik Falkenburg (210432)

December 2018

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Th...

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease

Amir, A.L.
Hagedoorn, R.S.
Luxemburg-Heijs, S.A.P. van
Marijt, E.W.A.
Kruisselbrink, A.B.
Falkenburg, J.H.F.
Heemskerk, M.H.M.

February 2012

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease

Amir, Avital L.
Hagedoorn, Renate S.
van Luxemburg-Heijs, Simone A.P.
Marijt, Erik W.A.
Kruisselbrink, Alwine B.
Frederik Falkenburg, J.H.
Heemskerk, Mirjam H.M.

February 2012

After HLA class I-mismatched stem cell transplantation, allo-HLA–directed CD8 T cell responses can b...

HLA-DP specific responses in allogeneic stem cell transplantation

Rutten, C.E.

June 2013

Clinical studies demonstrated that HLA-DPB1 mismatched stem cell transplantation (SCT) is associated...

Patient HLA-DP–Specific CD4+ T Cells from HLA-DPB1–Mismatched Donor Lymphocyte Infusion Can Induce Graft-versus-Leukemia Reactivity in the Presence or Absence of Graft-versus-Host Disease

Rutten, Caroline E.
van Luxemburg-Heijs, Simone A.P.
Halkes, Constantijn J.M.
van Bergen, Cornelis A.M.
Marijt, Erik W.A.
Oudshoorn, Machteld
Griffioen, Marieke
Falkenburg, J.H. Frederik

January 2013

AbstractClinical studies have demonstrated that HLA-DPB1–mismatched allogeneic stem cell transplanta...

Biology and clinical relevance of T-cell allo-HLA reactivity

Amir, A.

June 2012

Allo-HLA reactive T-cells can mediate graft versus host disease (GVHD) after HLA mismatched stem cel...

Targeting allogeneic HLA-DP: diversity, specificity and magnitude of T-cell responses

Laghmouchi, A.

October 2022

Following HLA-DP-mismatched alloSCT and DLI, donor T cells show allogeneic (allo) HLA-DP-specific re...

Priming of allo-HLA-DP-specific reactivity from the naive T cell compartment is not exclusively mediated by professional antigen-presenting cells

Laghmouchi, A.
Hoogstraten, C.
Falkenburg, J.H.F.
Jedema, I.

July 2020

Allogeneic (allo) stem cell transplantation is applied to patients suffering from hematologic malign...

CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

Peter van Balen
Cornelis A. M. van Bergen
Simone A. P. van Luxemburg-Heijs
Wendy de Klerk
Esther H. M. van Egmond
Sabrina A. J. Veld
Constantijn J. M. Halkes
Jaap-Jan Zwaginga
Jaap-Jan Zwaginga
Marieke Griffioen
Inge Jedema
J. H. Frederik Falkenburg

December 2018

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Th...

Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It.

Ali, Jason M
Negus, Margaret C
Conlon, Thomas M
Harper, Ines G
Qureshi, M Saeed
Motallebzadeh, Reza
Willis, Richard
Saeb-Parsy, Kourosh
Bolton, Eleanor
Bradley, John
Pettigrew, Gavin

February 2016

MHC alloantigen is recognized by two pathways: "directly," intact on donor cells, or "indirectly," a...

Early CD4+T-Cell Effector Alloreactivity Towards Multiple Mismatched HLA Class II Alleles Is Associated with Graft Predominance after Double Umbilical Cord Blood Transplantation (dUCBT)

Cornelissen, J.J.
Wijers, R.
Bergen, C.A.M. van
Somers, J.
Braakman, E.
Gratama, J.W.
Debets, R.
Falkenburg, J.H.F.
Lamers, C.

December 2015

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Donor T-cells for hematopoietic-restricted minor histocompatibility antigens are induced in patients with combined Graft-versus-Leukemia and Graft-versus-Host disease

Pont, M.J.
Bergen, C.A.M. van
Honders, M.W.
Luxemburg-Heijs, S.A.P. van
Kester, M.G.D.
Falkenburg, J.H.F.
Griffioen, M.

November 2014

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation.

Milosevic, S.
Bachnick, B.
Karim, K.
Bornkamm, G.W.
Witter, K.
Gerbitz, A.
Mautner, J.
Behrends, U.

January 2010

BACKGROUND: After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells m...

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation

Herr, W.
Eichinger, Y.
Beshay, J.
Bloetz, A.
Vatter, S.
Mirbeth, C.
Distler, E.
Hartwig, U. F.
Thomas, S.

January 2017

Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogen...

CD4(+) T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

Lamers, C.H.J.
Wijers, R.
Bergen, C.A.M. van
Somers, J.A.E.
Braakman, E.
Gratama, J.W.
Debets, R.
Falkenburg, J.H.F.
Cornelissen, J.J.

October 2016

HematologyImmunobiology of allogeneic stem cell transplantation and immunotherapy of hematological d...

Image_1_CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II.TIF

Peter van Balen (4889299)
Cornelis A. M. van Bergen (5657533)
Simone A. P. van Luxemburg-Heijs (6092510)
Wendy de Klerk (6092513)
Esther H. M. van Egmond (6092516)
Sabrina A. J. Veld (3595007)
Constantijn J. M. Halkes (353655)
Jaap-Jan Zwaginga (6092519)
Marieke Griffioen (119817)
Inge Jedema (4889290)
J. H. Frederik Falkenburg (210432)

December 2018

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Th...

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease

Amir, A.L.
Hagedoorn, R.S.
Luxemburg-Heijs, S.A.P. van
Marijt, E.W.A.
Kruisselbrink, A.B.
Falkenburg, J.H.F.
Heemskerk, M.H.M.

February 2012

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease

Amir, Avital L.
Hagedoorn, Renate S.
van Luxemburg-Heijs, Simone A.P.
Marijt, Erik W.A.
Kruisselbrink, Alwine B.
Frederik Falkenburg, J.H.
Heemskerk, Mirjam H.M.

February 2012

After HLA class I-mismatched stem cell transplantation, allo-HLA–directed CD8 T cell responses can b...

HLA-DP specific responses in allogeneic stem cell transplantation

Rutten, C.E.

June 2013

Clinical studies demonstrated that HLA-DPB1 mismatched stem cell transplantation (SCT) is associated...

Patient HLA-DP–Specific CD4+ T Cells from HLA-DPB1–Mismatched Donor Lymphocyte Infusion Can Induce Graft-versus-Leukemia Reactivity in the Presence or Absence of Graft-versus-Host Disease

Rutten, Caroline E.
van Luxemburg-Heijs, Simone A.P.
Halkes, Constantijn J.M.
van Bergen, Cornelis A.M.
Marijt, Erik W.A.
Oudshoorn, Machteld
Griffioen, Marieke
Falkenburg, J.H. Frederik

January 2013

AbstractClinical studies have demonstrated that HLA-DPB1–mismatched allogeneic stem cell transplanta...

Biology and clinical relevance of T-cell allo-HLA reactivity

Amir, A.

June 2012

Allo-HLA reactive T-cells can mediate graft versus host disease (GVHD) after HLA mismatched stem cel...

Targeting allogeneic HLA-DP: diversity, specificity and magnitude of T-cell responses

Laghmouchi, A.

October 2022

Following HLA-DP-mismatched alloSCT and DLI, donor T cells show allogeneic (allo) HLA-DP-specific re...

Priming of allo-HLA-DP-specific reactivity from the naive T cell compartment is not exclusively mediated by professional antigen-presenting cells

Laghmouchi, A.
Hoogstraten, C.
Falkenburg, J.H.F.
Jedema, I.

July 2020

Allogeneic (allo) stem cell transplantation is applied to patients suffering from hematologic malign...

CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

Peter van Balen
Cornelis A. M. van Bergen
Simone A. P. van Luxemburg-Heijs
Wendy de Klerk
Esther H. M. van Egmond
Sabrina A. J. Veld
Constantijn J. M. Halkes
Jaap-Jan Zwaginga
Jaap-Jan Zwaginga
Marieke Griffioen
Inge Jedema
J. H. Frederik Falkenburg

December 2018

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Th...

Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It.

Ali, Jason M
Negus, Margaret C
Conlon, Thomas M
Harper, Ines G
Qureshi, M Saeed
Motallebzadeh, Reza
Willis, Richard
Saeb-Parsy, Kourosh
Bolton, Eleanor
Bradley, John
Pettigrew, Gavin

February 2016

MHC alloantigen is recognized by two pathways: "directly," intact on donor cells, or "indirectly," a...

Early CD4+T-Cell Effector Alloreactivity Towards Multiple Mismatched HLA Class II Alleles Is Associated with Graft Predominance after Double Umbilical Cord Blood Transplantation (dUCBT)

Cornelissen, J.J.
Wijers, R.
Bergen, C.A.M. van
Somers, J.
Braakman, E.
Gratama, J.W.
Debets, R.
Falkenburg, J.H.F.
Lamers, C.

December 2015

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Donor T-cells for hematopoietic-restricted minor histocompatibility antigens are induced in patients with combined Graft-versus-Leukemia and Graft-versus-Host disease

Pont, M.J.
Bergen, C.A.M. van
Honders, M.W.
Luxemburg-Heijs, S.A.P. van
Kester, M.G.D.
Falkenburg, J.H.F.
Griffioen, M.

November 2014

Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation.

Milosevic, S.
Bachnick, B.
Karim, K.
Bornkamm, G.W.
Witter, K.
Gerbitz, A.
Mautner, J.
Behrends, U.

January 2010

BACKGROUND: After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells m...

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation

Herr, W.
Eichinger, Y.
Beshay, J.
Bloetz, A.
Vatter, S.
Mirbeth, C.
Distler, E.
Hartwig, U. F.
Thomas, S.

January 2017

Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogen...

CD4 T-cells directed against mismatched HLA-DP isolated following donor CD4 T-cell infusion after allogeneic stem cell transplantation show differential tissue recognition

Abstract

Extracted data

CD4 T-cells directed against mismatched HLA-DP isolated following donor CD4 T-cell infusion after allogeneic stem cell transplantation show differential tissue recognition

Abstract

Extracted data

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