Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
- Arnau-Soler, A.
- Macdonald-Dunlop, E.
- Adams, M.J.
- Clarke, T.K.
- MacIntyre, D.J.
- Milburn, K.
- Navrady, L.
- Hayward, C.
- McIntosh, A.M.
- Thomson, P.A.
- Wray, N.R.
- Ripke, S.
- Mattheisen, M.
- Trzaskowski, M.
- Byrne, E.M.
- Abdellaoui, A.
- Agerbo, E.
- Air, T.M.
- Andlauer, T.F.M.
- Bacanu, S.A.
- Baekvad-Hansen, M.
- Beekman, A.T.F.
- Bigdeli, T.B.
- Binder, E.B.
- Blackwood, D.H.R.
- Bryois, J.
- Buttenscon, H.N.
- Bybjerg-Grauholm, J.
- Cai, N.
- Castelao, E.
- Christensen, J.H.
- Coleman, J.R.I.
- Colodro-Conde, L.
- Couvy-Duchesne, B.
- Craddock, N.
- Rawford, G.E.C.
- Davies, G.
- Deary, I.J.
- Degenhardt, F.
- Derks, E.M.
- Direk, N.
- Dolan, C.V.
- Dunn, E.C.
- Eley, T.C.
- Escott-Price, V.
- Kiadeh, F.F.H.
- Finucane, H.K.
- Foo, J.C.
- Forstner, A.J.
- Frank, J.
- Gaspar, H.A.
- Gill, M.
- Goes, F.S.
- Gordon, S.D.
- Grove, J.
- Hall, L.S.
- Hansen, C.S.
- Hansen, T.F.
- Herms, S.
- Hickie, I.B.
- Hoffmann, P.
- Homuth, G.
- Horn, C.
- Hottenga, J.J.
- Hougaard, D.M.
- Ising, M.
- Jansen, R.
- Jones, I.
- Jones, L.A.
- Jorgenson, E.
- Knowles, J.A.
- Kohane, I.S.
- Kraft, J.
- Kretzschmar, W.W.
- Krogh, J.
- Kutalik, Z.
- Li, Y.H.
- Lind, P.A.
- Macintyre, D.J.
- MacKinnon, D.F.
- Maier, R.M.
- Maier, W.
- Marchini, J.
- Mbarek, H.
- McGrath, P.
- McGuffin, P.
- Medland, S.E.
- Mehta, D.
- Middeldorp, C.M.
- Mihailov, E.
- Milaneschi, Y.
- Milani, L.
- Mondimore, F.M.
- Montgomery, G.W.
- Mostafavi, S.
- Mullins, N.
- Nauck, M.
- Ng, B.
- Nivard, M.G.
- Nyholt, D.R.
- O'Reilly, P.F.
- Oskarsson, H.
- Owen, M.J.
- Painter, J.N.
- Pedersen, C.B.
- Pedersen, M.G.
- Peterson, R.E.
- Pettersson, E.
- Peyrot, W.J.
- Pistis, G.
- Posthuma, D.
- Quiroz, J.A.
- Qvist, P.
- Rice, J.P.
- Riley, B.P.
- Rivera, M.
- Mirza, S.S.
- Schoevers, R.
- Schulte, E.C.
- Shen, L.
- Shi, J.X.
- Shyn, S.I.
- Sigurdsson, E.
- Sinnamon, G.C.B.
- Smit, J.H.
- Smith, D.J.
- Stefansson, H.
- Steinberg, S.
- Streit, F.
- Strohmaier, J.
- Tansey, K.E.
- Teismann, H.
- Teumer, A.
- Thompson, W.
- Thorgeirsson, T.E.
- Traylor, M.
- Treutlein, J.
- Trubetskoy, V.
- Uitterlinden, A.G.
- Umbricht, D.
- Auwera, S. van der
- Hemert, A.M. van
- Viktorin, A.
- Visscher, P.M.
- Wang, Y.P.
- Webb, B.T.
- Weinsheimer, S.M.
- Wellmann, J.
- Willemsen, G.
- Witt, S.H.
- Wu, Y.
- Xi, H.L.S.
- Yang, J.
- Zhang, F.T.
- Arolt, V.
- Baune, B.T.
- Berger, K.
- Boomsma, D.I.
- Cichon, S.
- Dannlowski, U.
- Geus, E.J.C. de
- DePaulo, J.R.
- Domenici, E.
- Domschke, K.
- Esko, T.
- Grabe, H.J.
- Hamilton, S.P.
- Heath, A.C.
- Kendler, K.S.
- Kloiber, S.
- Lewis, G.
- Li, Q.Q.S.
- Lucae, S.
- Madden, P.A.F.
- Magnusson, P.K.
- Martin, N.G.
- Metspalu, A.
- Mors, O.
- Mortensen, P.B.
- Muller-Myhsok, B.
- Nordentoft, M.
- Nothen, M.M.
- O'Donovan, M.C.
- Paciga, S.A.
- Pedersen, N.L.
- Penninx, B.W.J.H.
- Perlis, R.H.
- Porteous, D.J.
- Potash, J.B.
- Preisig, M.
- Rietschel, M.
- Schaefer, C.
- Schulze, T.G.
- Smoller, J.W.
- Stefansson, K.
- Tiemeier, H.
- Uher, R.
- Volzke, H.
- Weissman, M.M.
- Werge, T.
- Lewis, C.M.
- Levinson, D.F.
- Breen, G.
- Borglum, A.S.D.
- Sullivan, P.F.
- Generation Scotland
- Psychiat Genomics Consortium
DOIAbstract
Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 x 10(-6)). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 x 10(-9); total SLE) and rs170700...
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