Structural, biochemical and cellular analyses show that bacterial antigens can mimic gliadin epitopes involved in celiac disease being presented by HLA-DQ2.5 and recognized by T cells derived from patients.The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear. Here we identify microbially derived mimics of gliadin epitopes and a parental bacterial protein that is naturally processed by antigen-presenting cells and activated gliadin reactive HLA-DQ2.5-restricted T cells derived from CeD patients. Crystal structures of T cell...
Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induc...
In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the imm...
Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat glu...
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disor...
Abstract-This paper presents a new hypothesis for the etiology and pathogenesis of cehac disease (CD...
SummaryCeliac disease is a human leukocyte antigen (HLA)-DQ2- and/or DQ8-associated T cell-mediated ...
Celiac disease is a T cell–mediated disease induced by dietary gluten, a component of which is gliad...
Background Celiac disease is a small intestine inflammatory disorder with multiple organ involvement...
ABSTRACT Class II major histocompatibility molecules confer disease risk in Celiac disease (CD) by ...
The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2.5 and HLA-DQ2.2, are impl...
Celiac disease (CeD) provides an opportunity to study the specificity underlying human T-cell respon...
Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten lead...
Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut to a...
Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to infl...
Coeliac disease, the most common intestinal disorder of western populations, is an autoimmune entero...
Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induc...
In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the imm...
Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat glu...
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disor...
Abstract-This paper presents a new hypothesis for the etiology and pathogenesis of cehac disease (CD...
SummaryCeliac disease is a human leukocyte antigen (HLA)-DQ2- and/or DQ8-associated T cell-mediated ...
Celiac disease is a T cell–mediated disease induced by dietary gluten, a component of which is gliad...
Background Celiac disease is a small intestine inflammatory disorder with multiple organ involvement...
ABSTRACT Class II major histocompatibility molecules confer disease risk in Celiac disease (CD) by ...
The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2.5 and HLA-DQ2.2, are impl...
Celiac disease (CeD) provides an opportunity to study the specificity underlying human T-cell respon...
Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten lead...
Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut to a...
Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to infl...
Coeliac disease, the most common intestinal disorder of western populations, is an autoimmune entero...
Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induc...
In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the imm...
Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat glu...