Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease

Study Funding The Norwegian ParkWest study has been funded by the Research Council of Norway (grant 177966) and the Western Norway Regional Health Authority (grant 911218) and the Norwegian Parkinsons Disease Association. J.M.-G. and G.A. are supported by the Research Council of Norway (grant 287842). PINE was supported by Parkinson’s UK (grants G0502, G0914, and G1302), Scottish Government Chief Scientist Office, BMA Doris Hillier Award, the BUPA Foundation, NHS Grampian Endowments, and RS MacDonald Trust. The NYPUM study has been funded by the Swedish Medical Research Council, the Swedish Parkinson’s Disease Association, the Swedish Parkinson Foundation, and the Västerbotten County Council. Disclosure J. Maple-Grødem, I. Dalen, and O.-B. Tysnes report no disclosures relevant to the manuscript. A. Macleod reports fellowship funding from the Scottish Chief Scientist Office (PCL/17/10) and grant funding from the Academy of Medical Sciences and NHS Grampian Endowments. L. Forsgren reports no disclosures relevant to the manuscript. C. Counsell reports NHS Grampian Endowments and RS Macdonald Trust. G. Alves reports Norwegian Research Council grant 287842, principal investigator, 2019–2022 and support from University of Stavanger, Norwegian Parkinson Research Foundation, and Reberg's Legacy. Go to Neurology.org/N for full disclosures. Acknowledgment The authors thank the patients for participating in the studies; ParkWest thanks all members of the Norwegian ParkWest study group and other personnel involved in the study; NYPUM thanks the study nurse/coordinator Mona Edström and laboratory technician Jörgen Andersson for database management; and PINE thanks the research fellows (Kate Taylor, Robert Caslake, and David McGhee) and study nurses (Clare Harris, Joanna Gordon, Anne Hayman, and Hazel Forbes) who assessed participants, the secretaries (Susan Kilpatrick and Pam Rebecca), the data management team (Katie Wilde and David Ritchie), and the clinicians who referred patients to the PINE study.Peer reviewedPublisher PD