[[abstract]]BACKGROUND: Club cells play an important role in maintaining lung homeostasis and aryl hydrocarbon receptor (AhR) is known to be important in xenobiotic metabolism, but its role in regulating club cells is currently unknown. METHODS: To this end, mice with club cell-specific AhR deficiency were generated and evaluated in a model of antigen (ovalbumin, OVA)-induced airway inflammation for the number of infiltrating inflammatory cells, the levels of cytokines and CC10 and Notch signaling by standard methods. RESULTS: After OVA sensitization and challenge, Scgb1a1-Cre; Ahr(flox/flox) mice showed aggravated levels of pulmonary inflammation with increased levels of inflammatory cells and cytokines 1 day after challenge as compared to...
International audienceINTRODUCTION: The aryl hydrocarbon receptor (AhR) is a ligand-activated transc...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-ma...
[[abstract]]Rationale: Vascular endothelial growth factor (VEGF) is a critical regulator of angiogen...
[[abstract]]BACKGROUND: Club cells play an important role in maintaining lung homeostasis and aryl h...
[[abstract]]Club cells are critical in maintaining airway integrity via, in part, secretion of immun...
BACKGROUND: The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon rece...
The lung epithelial barrier serves as a guardian towards environmental insults and responds to aller...
The aryl hydrocarbon receptor (AhR) is a known modulator of immune responses. In a mouse model of in...
Emphysema, a component of chronic obstructive pulmonary disease (COPD), is characterized by irrevers...
The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants ...
The aryl-hydrocarbon receptor (AHR) is an intracellular sensor of aromatic hydrocarbons that sits at...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates the me...
International audienceBACKGROUND: The aryl hydrocarbon receptor (AhR) has gradually emerged as a reg...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-ma...
The aryl hydrocarbon receptor (AhR) is involved in the regulation of immune responses, T-cell differ...
International audienceINTRODUCTION: The aryl hydrocarbon receptor (AhR) is a ligand-activated transc...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-ma...
[[abstract]]Rationale: Vascular endothelial growth factor (VEGF) is a critical regulator of angiogen...
[[abstract]]BACKGROUND: Club cells play an important role in maintaining lung homeostasis and aryl h...
[[abstract]]Club cells are critical in maintaining airway integrity via, in part, secretion of immun...
BACKGROUND: The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon rece...
The lung epithelial barrier serves as a guardian towards environmental insults and responds to aller...
The aryl hydrocarbon receptor (AhR) is a known modulator of immune responses. In a mouse model of in...
Emphysema, a component of chronic obstructive pulmonary disease (COPD), is characterized by irrevers...
The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants ...
The aryl-hydrocarbon receptor (AHR) is an intracellular sensor of aromatic hydrocarbons that sits at...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates the me...
International audienceBACKGROUND: The aryl hydrocarbon receptor (AhR) has gradually emerged as a reg...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-ma...
The aryl hydrocarbon receptor (AhR) is involved in the regulation of immune responses, T-cell differ...
International audienceINTRODUCTION: The aryl hydrocarbon receptor (AhR) is a ligand-activated transc...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-ma...
[[abstract]]Rationale: Vascular endothelial growth factor (VEGF) is a critical regulator of angiogen...