Connective tissue growth factor (CTGF, CCN2) is a matricellular protein which plays key roles in normal mammalian development and in tissue homeostasis and repair. In pathological conditions, dysregulated CCN2 has been associated with cancer, cardiovascular disease, and tissue fibrosis. In this study, genetic manipulation of the CCN2 gene was employed to investigate the role of CCN2 expression in vitro and in experimentally-induced models of pulmonary fibrosis and pulmonary arterial hypertension (PAH). Knocking down CCN2 using siRNA reduced expression of pro-fibrotic markers (fibronectin p < 0.01, collagen type I p < 0.05, α-SMA p < 0.0001, TIMP-1 p < 0.05 and IL-6 p < 0.05) in TGF-β-treated lung fibroblasts derived from systemic sclerosis ...
Connective tissue growth factor (CTGF) is a secreted, extracellular matrix (ECM) bound signaling mol...
AbstractConnective tissue growth factor (CTGF) plays an important role in lung fibrosis. In this stu...
BACKGROUND: One of the main contributors to maladaptive cardiac remodeling is fibrosis. Connective t...
OBJECTIVE: Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic sclerosis (SSc)...
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive and ultimately lethal disease of the l...
Fibrotic disease is a significant cause of mortality. CCN2 (connective tissue growth factor [CTGF]),...
Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contribu...
Members of the C(Cyr61) C(CTGF) N(Nov) family of matricellular proteins are involved in multiple asp...
Connective tissue growth factor (CCN2) is a multifunctional matricellular protein, which is frequent...
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involv...
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized ...
Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts a...
Connective tissue growth factor (CTGF) is a signaling molecule that primarily functions in extracell...
Pulmonary fibrosis is a severely disabling disease often leading to death. CCN2 (Cellular Communicat...
Fibrotic disorders, including the inflammatory connective tissue disease systemic sclerosis (SSc), c...
Connective tissue growth factor (CTGF) is a secreted, extracellular matrix (ECM) bound signaling mol...
AbstractConnective tissue growth factor (CTGF) plays an important role in lung fibrosis. In this stu...
BACKGROUND: One of the main contributors to maladaptive cardiac remodeling is fibrosis. Connective t...
OBJECTIVE: Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic sclerosis (SSc)...
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive and ultimately lethal disease of the l...
Fibrotic disease is a significant cause of mortality. CCN2 (connective tissue growth factor [CTGF]),...
Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contribu...
Members of the C(Cyr61) C(CTGF) N(Nov) family of matricellular proteins are involved in multiple asp...
Connective tissue growth factor (CCN2) is a multifunctional matricellular protein, which is frequent...
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involv...
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized ...
Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts a...
Connective tissue growth factor (CTGF) is a signaling molecule that primarily functions in extracell...
Pulmonary fibrosis is a severely disabling disease often leading to death. CCN2 (Cellular Communicat...
Fibrotic disorders, including the inflammatory connective tissue disease systemic sclerosis (SSc), c...
Connective tissue growth factor (CTGF) is a secreted, extracellular matrix (ECM) bound signaling mol...
AbstractConnective tissue growth factor (CTGF) plays an important role in lung fibrosis. In this stu...
BACKGROUND: One of the main contributors to maladaptive cardiac remodeling is fibrosis. Connective t...