Add to ORKGInflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in fem...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles ...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
The normal function of ovaries, along with the secretion of sex hormones, is among the most importan...
Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...
This study shows that lack of ovarian activity has a negative impact on the life span of female mice...
While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological ...
The mammalian female is born with a limited ovarian reserve of primordial follicles. These primordia...
Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles ...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
The normal function of ovaries, along with the secretion of sex hormones, is among the most importan...
Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...
This study shows that lack of ovarian activity has a negative impact on the life span of female mice...
While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological ...
The mammalian female is born with a limited ovarian reserve of primordial follicles. These primordia...
Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...