A Comparative Study of Efficacy of Analgesiaand Anaesthesia between Intrathecal ButorphanolAndFentanyl with Bupivacaine 0.5% Heavy for Lower Limb Orthopedic Surgery: A Prospective Randomized Study

Background: Subarachnoid block is a common anesthesia procedure for lower abdominal or lower limb surgeries including perineal surgeries. Usage of opioids in conjunction with local anesthetic for spinal anesthesia has been associated with decreased pain scores and reduced analgesic requirement in the post-operative period. Objectives: To assess the efficacy of anesthesia and analgesia between intrathecalfentanyl and butorphanol withbupivacaine heavy 0.5% for lower limb orthopaedic surgery. Design: Prospective randomized control trial Method of collection of data: This prospective, randomized, double blind study was conducted after approval from the institutional ethics committee and written informed consent of patients. About 100 patients, aged 18-75 years, belonging to American society of anesthesiologists (ASA) physical status 1 or 2 and scheduled for elective, lower limb orthopedic surgeries was randomized into two groups. Group A received 2.5ml of 0.5% hyperbaricbupivacaine with 0.5ml (25μg fentanyl) a total volume of 3ml intrathecally. The Butorphanolwas diluted using distilled sterile water to obtain 25μg in 0.5ml. This was then added to 2.5ml of 0.5% hyperbaric bupivacaine to make a total volume of 3ml which was given to group B. Results: The times required for onset of sensory and motor blockade were comparable among the two groups. Significantly slower block regression to S2 level was observed in the group receiving intrathecalbutorphanolas compared to intrathecalfentanyl (P<.0001). A higher number of patients in group A requested for rescue analgesia during the postoperative period than in group B (9 versus 2; P=0.0238). The average times to first request for rescue analgesia were 255.74±10.110 minutes and 290.70±7.117 minutes in group A and B, respectively (P<0.0001). Conclusion: Both 25μg fentanyl and 25μg butorphanol given intrathecally along with 12.5 mg of hyperbaric bupivacaine provide effective anesthesia for lower limb surgeries. Intrathecalbupivacaine-butorphanol mixture provides longer duration of sensory blockade and superior analgesia than intrathecalfentanyl-bupivacaine mixture