Evaluation of inflammatory mediators in newly diagnosed type II diabetic patients without hypertension

Background:The present study was conducted to assess the role of inflammation in T2DM by measuring the levels of cytokines, including IL-6 (pg/ml),hs-CRP(mg/L), TNF- alpha (pg/ml) in T2DM.Materials & Methods:34 type II diabetes mellitus patients and equal numbers of normotensive non diabetic subjects were recruited. Glycated hemoglobin (HbA1c) levels, IL-6 (pg/ml),hs-CRP(mg/L), TNF- alpha (pg/ml) were evaluated.Results: IL-6 level of 16.2±4.2 in Group I and 3.8±1.4 in control patients. In diabetic patients HS CRP levels were observed to be 1.5±0.24 (mg/L) and 0.5±0.04 (mg/L) in control subjects. TNF- alpha levels were observed to be 34.6 in diabetic patients and 14.2 in control subjects. All inflammatory markers studied in our study showed statistically significant difference.Conclusion:Patients with established T2DM, had different cytokine profile than healthy controls. Further large prospective studies are required to evaluate a temporal relation between baseline levels of inflammatory markers and incidence of T2D