The livelihood of human cells is heavily dependent on the ability to modulate the presence of highly reactive oxygen-based molecules termed reactive oxygen species (ROS). In excess, ROS facilitate oxidative damage to the macromolecules of cellular life. SODs are the major family of antioxidant proteins that prevent the buildup of overwhelming amounts of ROS within cells. Sometimes dubbed the “first line of defense” against oxidative damage, SODs defend against the harmful accumulation of ROS by eliminating superoxide. Superoxide is a ROS itself that is also a precursor to much more harmful ROS molecules. MnSOD is the manganese containing form of human SODs that dwells within the mitochondria and is responsible for protecting the organelle a...
Manganese centers that react with O2 and its reduced derivatives mediate a diverse array of biologic...
The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of ...
Between 2.8 and 2.4 billion years ago Nature designed a method to catalytically split water into oxy...
Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from reactive oxyg...
Human Mn-containing superoxide dismutase (hMnSOD) is amitochondrial enzyme that metabolizes superoxi...
Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protect...
AbstractSuperoxide dismutases (SODs) catalyze the de toxification of superoxide. SODs therefore acqu...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
Gln146 is a highly conserved outer-sphere amino acid residue at the active site of MnSOD. It serves ...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important co...
We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-dire...
Manganese-bound superoxide dismutase (MnSOD) is a very important antioxidant enzyme. The mechanism b...
Manganese superoxide dismutases (MnSODs) are enzymes that convert two molecules of the poisonous sup...
AbstractThe reaction of HO2. with the allylic groups of lipids initiates their peroxidation and auto...
Manganese centers that react with O2 and its reduced derivatives mediate a diverse array of biologic...
The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of ...
Between 2.8 and 2.4 billion years ago Nature designed a method to catalytically split water into oxy...
Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from reactive oxyg...
Human Mn-containing superoxide dismutase (hMnSOD) is amitochondrial enzyme that metabolizes superoxi...
Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protect...
AbstractSuperoxide dismutases (SODs) catalyze the de toxification of superoxide. SODs therefore acqu...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
Gln146 is a highly conserved outer-sphere amino acid residue at the active site of MnSOD. It serves ...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important co...
We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-dire...
Manganese-bound superoxide dismutase (MnSOD) is a very important antioxidant enzyme. The mechanism b...
Manganese superoxide dismutases (MnSODs) are enzymes that convert two molecules of the poisonous sup...
AbstractThe reaction of HO2. with the allylic groups of lipids initiates their peroxidation and auto...
Manganese centers that react with O2 and its reduced derivatives mediate a diverse array of biologic...
The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of ...
Between 2.8 and 2.4 billion years ago Nature designed a method to catalytically split water into oxy...