Role of Effectiveness of Autologous Platelet Rich Plasma in Healing of Chronic Ulcer

INTRODUCTION: Chronic ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. AIM AND OBJECTIVE: To study the role of effectiveness of autologous platelet rich plasma in healing of chronic ulcers. To study the percentage of reduction of area of the ulcer every week for 4 weeks. METHODS: Patients admitted in surgery ward for chronic ulcer between age group 18-85 during December 2017 to June 2019 were studied. Individuals with systemic disease or history of anticoagulant, immunosuppressive, pregnant women, patients with severe cardiovascular disorder, bleeding disorder and anemia were excluded. Detailed history, clinical examination and lab investigations were taken and analyzed. Autologous platelet rich plasma was prepared from the patients and was applied to the ulcer and regular dressings were done. Wound area was calculated every week for 4 weeks. The treatment outcome was defined as a percentage change of the area, which was calculated as initial measurement minus assessment day measurement divided by initial measurement. CONCLUSION: 51 cases were studied. Various factors like age group, gender, etiology of the ulcer, percentage change of area of the ulcer is calculated and found that autologous platelet rich plasma is effective in healing of chronic ulcers. The mean percentage area of reduction of ulcer in the study is 73.0124% in 4 weeks, which is a very significant reduction in the area of the ulcer