Renal Angiomyolipoma: A Clinicopathological study in a Tertiary Care Centre

INTRODUCTION: Angiomyolipoma (AML) is a benign mesenchymal tumour with an incidence of less than 1% of surgically excised renal tumours. AML is composed of variable proportions of dysmorphic blood vessels (angio), epithelioid smooth muscle (myo), spindle cells and mature adipose tissue(lipo).Though these tumours are mostly seen in kidney, they are also seen in spleen, uterus, liver and fallopian tube. The term “angiomyolipoma” was first coined by Morgan in 1951 to describe benign renal tumor composed of blood vessels, muscle, and fat. Angiomyolipoma belongs to the family of lesions called (PEComas) perivascular epithelioid cell tumours, recognised by World Health Organization (WHO) in 2002. These PEComas includes angiomyolipoma(AML), lymphangioleiomyomatosis (LAM) and other perivascular epithelioid cell tumours occurring in soft tissue, cutaneous and visceral sites in the body. OBJECTIVES: 1. To evaluate the prevalence and clinicopathological characteristics of renal angiomyolipoma. 2. To evaluate the association of renal angiomyolipoma with renal or other malignancies and with tuberous sclerosis. METHODS: This retrospective descriptive study was carried out in the Department of Pathology, Christian Medical College, and Vellore during the period 2017-2019 on diagnosed cases of renal angiomyolipoma from 2001 to 2018. Demographic and clinical details were obtained from the electronic medical records. The histopathological and immunohistochemical details of all cases were reviewed either from archives or by examining the slides. Data analysis was done using Statistical Package for Social Services (SPSS) software Version 16.0. The association between the categorical variables was done using Chi-square statistics/Fisher exact test where a P value of