Literature on higher education presents a gap between the ubiquitously used rankings of universities and a more comprehensive and qualitative measurement of national higher education systems. A glance at the university system performance at the regional scale may help to bridge this gap. In the present paper the quality of the university system at the regional level is analyzed in relation to a spectrum of functions: providing the appropriate human capital, promoting social mobility and cohesion, fostering research and innovation, and cooperating with industry and enterprises. A comparative study on regional university systems in Europe is carried out using a university-level dataset collected by the EUMIDA Consortium. The dataset, which re...