Radioimmunotherapy Is Effective Against High-Inoculum Cryptococcus Neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells
- BRYAN R. A.
- JIANG Z.
- HUANG X.
- MORGENSTERN Alfred
- BRUCHERTSEIFER Frank
- SELLERS R.
- CASADEVALL A.
- DADACHOVA E.
Publication date
March 2009
DOI Publisher
American Society for Microbiology ISSN
0066-4804 Journal
Antimicrobial Agents and ChemotherapyAbstract
We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.JRC.E.5-Nuclear chemistr
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