Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans
- BRYAN R. A.
- MORGENSTERN Alfred
- BRUCHERTSEIFER Frank
- CASADEVALL A.
- DADACHOVA E.
Publication date
November 2008
DOI Publisher
American Society for Microbiology ISSN
0066-4804 Journal
Antimicrobial Agents and ChemotherapyAbstract
We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.JRC.E.5-Nuclear chemistr
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