Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
- Demontis, Ditte
- Walters, Raymond K.
- Rajagopal, Veera M.
- Waldman, Irwin D.
- Grove, Jakob
- Als, Thomas D.
- Dalsgaard, Søren
- Ribasas, Marta
- Bybjerg-Grauholm, Jonas
- Bækvad-Hansen, Maria
- Werge, Thomas
- Nordentoft, Merete
- Mors, Ole
- Mortensen, Preben Bo
- (PGC), ADHD Working Group of the Psychiatric Genomics Consortium
- Andreassen, Ole A.
- Arranz, Maria Jesús
- Banaschewski, Tobias
- Bau, Claiton
- Bellgrove, Mark
- Biederman, Joseph
- Brikell, Isabell
- Buitelaar, Jan K.
- Burton, Christie L.
- Casas, Miguel
- Crosbie, Jennifer
- Doyle, Alysa E.
- Ebstein, Richard P.
- Elia, Josephine
- Elizabeth, Corfield C.
- Grevet, Eugenio
- Grizenko, Natalie
- Havdahl, Alexandra
- Hawi, Ziarih
- Hebebrand, Johannes
- Hervas, Amaia
- Hohmann, Sarah
- Haavik, Jan
- Joober, Ridha
- Kent, Lindsey
- Kuntsi, Jonna
- Langley, Kate
- Larsson, Henrik
- Lesch, Klaus-Peter
- Leung, Patrick W. L.
- Liao, Calwing
- Loo, Sandra K.
- Martin, Joanna
- Martin, Nicholas G.
- Medland, Sarah E.
- Miranda, Ana
- Mota, Nina Roth
- Oades, Robert D.
- Ramos-Quiroga, Josep Antoni
- Reif, Andreas
- Rietschel, Marcella
- Roeyers, Herbert
- Rohde, Luis Augusto
- Rothenberger, Aribert
- Rovira, Paula
- Sánchez-Mora, Cristina
- Schachar, Russell James
- Sengupta, Sarojini
- Artigas, Maria Soler
- Steinhausen, Hans-Christoph
- Thapar, Anita
- Witt, Stephanie H.
- Yang, Li
- Zayats, Tetyana
- Zhang-James, Yanli
- Cormand, Bru
- Hougaard, David M.
- Neale, Benjamin M.
- Franke, Barbara
- Faraone, Stephen V.
- Børglum, Anders D.
DOIAbstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behav...
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