Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models
- Rossi A.
- Rigotto G.
- Valente G.
- Giorgio V.
- Basso E.
- Filadi R.
- Pizzo P.
DOIAbstract
Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality
Add to ORKG