117 POSTER ANG1005, Paclitaxel conjugated to the angiopep brain transport vector for the treatment of brain cancer: preclinical studies
- Gabathuler, R.
- Demeule, M.
- Regina, A.
- Che, C.
- Thomas, F.
- Abulrob, A.
- Smith, Q.R.
- Stanimirovic, D.
- Beliveau, R.
- Castaigne, J.P.
DOIAbstract
In situ brain perfusion were used to assess the brain uptake of our conjugates. Analysis of tissues was done after extraction by LC-MS-MS or HPLC. Xenograft models of glioblastoma (U87) were established by intercranial stereotaxic injections of U87 cells in mice and rats.Peer reviewed: YesNRC publication: Ye
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