Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza\u2005A virus hemagglutinins

Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with \u3b12-3- and \u3b12-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.Peer reviewed: YesNRC publication: Ye