Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease

Xiong, Huaqi
Callaghan, Debbie
Wodzinska, Jolanta
Xu, Jiejing
Premyslova, Maryna
Liu, Qing-Yan
Connelly, John
Zhang, Wandong

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Publication date

August 2011

DOI

10.1007/s12264-011-1015-7

ISSN

1673-7067

Citation count (estimate)

Abstract

The double transgenic mouse model (APPswe/PS1dE9) of Alzheimer\u2019s disease (AD) has been widely used in experimental studies. \u3b2-Amyloid (A\u3b2) peptide is excessively produced in AD mouse brain, which affects synaptic function and the development of central nervous system. However, little has been reported on characterization of this model. The present study aimed to characterize this mouse AD model and its wild-type counterparts by biochemical and functional approaches.Peer reviewed: YesNRC publication: Ye