Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, we aimed to investigate the relationship between mean adipocyte area and obesity-related traits, and identify genetic factors associated with adipocyte cell size. To perform the first large-scale study of automatic adipocyte phenotyping using both histological and genetic data, we developed a deep learning-based method, the Adipocyte U-Net, to rapidly derive mean adipocyte area estimates from histology images. We validate our method using three state-of-the-art approaches; CellProfiler, Adiposoft and floating adipocytes frac...
Understanding adipocyte development, also known as adipogenesis, is crit- ical for improving metabol...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To get beyond the ''low-hanging fruits'' so far identified by genome-wide association (GWA) studies,...
Genetic studies have recently highlighted the importance of fat distribution, as well as overall adi...
Genetic studies have recently highlighted the importance of fat distribution, as well as overall adi...
Obesity affects more than 600 million people worldwide and causes 4 million excess deaths every year...
An increased adipocyte size relative to the size of fat depots, also denoted hypertrophic adipose mo...
Identifying the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose...
Diet and lifestyle have changed dramatically in the last few decades, leading to an increase in prev...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
BackgroundThe association between adiposity and cardiometabolic traits is well known from epidemiolo...
Obesity is an important driver of many cardiometabolic disorders (CMDs), including type 2 diabetes (...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
Understanding adipocyte development, also known as adipogenesis, is crit- ical for improving metabol...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To get beyond the ''low-hanging fruits'' so far identified by genome-wide association (GWA) studies,...
Genetic studies have recently highlighted the importance of fat distribution, as well as overall adi...
Genetic studies have recently highlighted the importance of fat distribution, as well as overall adi...
Obesity affects more than 600 million people worldwide and causes 4 million excess deaths every year...
An increased adipocyte size relative to the size of fat depots, also denoted hypertrophic adipose mo...
Identifying the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose...
Diet and lifestyle have changed dramatically in the last few decades, leading to an increase in prev...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
BackgroundThe association between adiposity and cardiometabolic traits is well known from epidemiolo...
Obesity is an important driver of many cardiometabolic disorders (CMDs), including type 2 diabetes (...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
Understanding adipocyte development, also known as adipogenesis, is crit- ical for improving metabol...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To get beyond the ''low-hanging fruits'' so far identified by genome-wide association (GWA) studies,...