Mortality in systemic lupus erythematosus
- Bernatsky, S
- Boivin, J-F
- Joseph, L
- Manzi, S
- Ginzler, E
- Gladman, D D
- Urowitz, M
- Fortin, P R
- Petri, M
- Barr, S
- Gordon, C
- Bae, S-C
- Isenberg, D
- Zoma, A
- Aranow, C
- Dooley, M-A
- Nived, O
- Sturfelt, G
- Steinsson, K
- Alarcón, G
- Senécal, J-L
- Zummer, M
- Hanly, J
- Ensworth, S
- Pope, J
- Edworthy, S
- Rahman, A
- Sibley, J
- El-Gabalawy, H
- McCarthy, T
- St Pierre, Y
- Clarke, A
- Ramsey-Goldman, R
DOIAbstract
To access Publisher full text version of this article. Please click on the hyperlink in Additional Link fieldOBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal diseas...
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