Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly
- Huang, Lin Chiang Sherlock
- Le, Dao
- Hsiao, I. Lun
- Fritsch-Decker, Susanne
- Hald, Christian
- Huang, S.-C.
- Chen, J.-K.
- Hwu, J. R.
- Weiss, C.
- Hsu, M.-H.
- Delaittre, Guillaume
Publication date
January 2021
DOI Publisher
Royal Society of Chemistry Language
EnglishAbstract
Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy
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