Introduction Amyotrophic lateral sclerosis (ALS) is a progressive and severe neurodegenerative disease caused by motor neuron death. There have as yet been no fundamental curative medicines, and the development of a medicine for ALS is urgently required. Induced pluripotent stem cell (iPSC)-based drug repurposing identified an Src/c-Abl inhibitor, bosutinib, as a candidate molecular targeted therapy for ALS. The objectives of this study are to evaluate the safety and tolerability of bosutinib for the treatment of patients with ALS and to explore the efficacy of bosutinib on ALS. This study is the first clinical trial of administered bosutinib for patients with ALS. Methods and analysis An open-label, multicentre phase I dose escalation stud...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder involving lo...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss ...
Amyotrophic Lateral Sclerosis (ALS) is a lethal motor neuron disorder, characterized by selective an...
筋萎縮性側索硬化症(ALS)患者さんを対象とした ボスチニブ第1相試験;iDReAM試験の成果報告 (論文発表). 京都大学プレスリリース. 2022-10-26.Phase I clinical t...
Introduction: Amyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease, causi...
Purpose: Amyotrophic lateral sclerosis (ALS) is an uncommon and aggressive neurodegenerative disorde...
Background: A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived...
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there a...
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting primarily ...
IntroductionAmyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease, causing...
Verena C Haringer, Summer B Gibson Clinical Neurosciences Center, Department of Neurology, Universit...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is a fatal neurodegenerative ...
Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that aff...
Objectives: Disease-modifying therapies for amyotrophic lateral sclerosis (ALS) are still not satisf...
Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that aff...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder involving lo...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss ...
Amyotrophic Lateral Sclerosis (ALS) is a lethal motor neuron disorder, characterized by selective an...
筋萎縮性側索硬化症(ALS)患者さんを対象とした ボスチニブ第1相試験;iDReAM試験の成果報告 (論文発表). 京都大学プレスリリース. 2022-10-26.Phase I clinical t...
Introduction: Amyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease, causi...
Purpose: Amyotrophic lateral sclerosis (ALS) is an uncommon and aggressive neurodegenerative disorde...
Background: A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived...
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there a...
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting primarily ...
IntroductionAmyotrophic lateral sclerosis (ALS) is an invariably lethal progressive disease, causing...
Verena C Haringer, Summer B Gibson Clinical Neurosciences Center, Department of Neurology, Universit...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is a fatal neurodegenerative ...
Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that aff...
Objectives: Disease-modifying therapies for amyotrophic lateral sclerosis (ALS) are still not satisf...
Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that aff...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder involving lo...
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss ...
Amyotrophic Lateral Sclerosis (ALS) is a lethal motor neuron disorder, characterized by selective an...