Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease of cattle with a detrimental impact on food quality and production. Research on bTB vaccines has predominantly been focused on proteinaceous antigens. However, mycobacteria have a thick and intricate lipid outer layer and lipids as well as lipopeptides are important for immune-evasion and virulence. In humans, lipid extracts of M. tuberculosis have been shown to elicit immune responses effective against M. tuberculosis in vitro. Chloroform-methanol extraction (CME) was applied to M. bovis BCG to obtain a hydrophobic antigen extract (CMEbcg) containing lipids and lipopeptides. CMEbcg stimulated IFN-γ+IL-2+ and IL-17A+IL-22+ polyfunctional T cells and elicited T ce...
Mycobacterium bovis (M. bovis) causes major economy and public health problem in numerous countries....
Bovine tuberculosis (bTB) remains a globally significant veterinary health problem. Defining correla...
Bovine tuberculosis (bTB) is caused by Mycobacterium bovis. The incidence of bTB is increasing in ca...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease of cattle with a detr...
The host/pathogen interaction is pivotal in defining the outcome of an infection. For cattle with b...
Bovine tuberculosis is of huge animal health and economic concern in the UK. Current ‘test and slaug...
Mycobacterium tuberculosis (M.tb) is responsible for more deaths globally than any other pathogen. T...
The development of novel vaccine strategies supplementing Mycobacterium bovis BCG (BCG) constitutes ...
Vaccination is being considered as part of a sustainable strategy for the control of bovine tubercul...
The generation of efficient candidate vaccines against bovine tuberculosis will contribute to the co...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis imposes a significant financial burden on ...
Vaccination of neonatal calves with Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces a sig...
Tuberculous infections caused by mycobacteria, especially tuberculosis of humans and cattle, are imp...
The definition of antigens for the diagnosis of human and bovine tuberculosis is a research priority...
Current efforts are aimed at optimizing the protective efficacy of Mycobacterium bovis BCG by the us...
Mycobacterium bovis (M. bovis) causes major economy and public health problem in numerous countries....
Bovine tuberculosis (bTB) remains a globally significant veterinary health problem. Defining correla...
Bovine tuberculosis (bTB) is caused by Mycobacterium bovis. The incidence of bTB is increasing in ca...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease of cattle with a detr...
The host/pathogen interaction is pivotal in defining the outcome of an infection. For cattle with b...
Bovine tuberculosis is of huge animal health and economic concern in the UK. Current ‘test and slaug...
Mycobacterium tuberculosis (M.tb) is responsible for more deaths globally than any other pathogen. T...
The development of novel vaccine strategies supplementing Mycobacterium bovis BCG (BCG) constitutes ...
Vaccination is being considered as part of a sustainable strategy for the control of bovine tubercul...
The generation of efficient candidate vaccines against bovine tuberculosis will contribute to the co...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis imposes a significant financial burden on ...
Vaccination of neonatal calves with Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces a sig...
Tuberculous infections caused by mycobacteria, especially tuberculosis of humans and cattle, are imp...
The definition of antigens for the diagnosis of human and bovine tuberculosis is a research priority...
Current efforts are aimed at optimizing the protective efficacy of Mycobacterium bovis BCG by the us...
Mycobacterium bovis (M. bovis) causes major economy and public health problem in numerous countries....
Bovine tuberculosis (bTB) remains a globally significant veterinary health problem. Defining correla...
Bovine tuberculosis (bTB) is caused by Mycobacterium bovis. The incidence of bTB is increasing in ca...