5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Piperidine derivatives for use in the treatment of pancreatic cancer

Vogel, Pierre
Duchosal, Michel
Aimable, Nahimana
Inmaculada, Robina
Mollinedo, Faustino
Nencioni, Alessio

August 2016

The present invention relates to novel piperidine derivatives having better cell growth inhibitory a...

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

McIver, Edward G
Bryans, Justin
Birchall, Kristian
Chugh, Jasveen
Drake, Thomas
Lewis, Stephen J
Osborne, Joanne
Smiljanic-Hurley, Ela
Tsang, William
Kamal, Ahmad
Levy, Alison
Newman, Michelle
Taylor, Debra
Arthur, J Simon C
Clark, Kristopher
Cohen, Philip

September 2012

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclop...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Reuillon, Tristan
Miller, Duncan
Myers, Stephanie
Molyneux, Lauren
Cano, Céline
Hardcastle, Ian
Griffin, Roger
Rigoreau, Laurent
Golding, Bernard
Noble, Martin

March 2016

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Newton, G
Stewart, M

January 2012

Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases assoc...

COMPOUNDS AND THEIR USES

Newton, G
Lord, C

February 2013

The invention provides a compound that is an inhibitor of one or both of TBK1 and IKKe, or a down-re...

Kinase inhibitors

Fischer, Peter
Fromont, Christophe
Stevenson, Brett
Butterworth, Sam
Iacobini, Greg
Greco, Graziella
Sanz, Miguel Garzon
Jones, Heulyn
Kaur, Divneet

November 2019

The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...

Piperazinylpyrimidine analogues as protein kinase inhibitors

Russu, Wade A.
Shallal, Hassan M.

December 2013

The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as prot...

MAP4K4 Inhibitors

Newton, G
Schneider, M

April 2019

This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections

Greff, Zoltán
Varga, Zoltán
Kéri, György
Õrfi, László
Pató, János
Bánhegyi, Péter
Szántai-kis, Csaba
Cole, Stewart
Hartkoorn, Ruben
Székely, Rita Edina

May 2017

The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formul...

Heterocyclic derivatives modulating the activity of certain protein kinases

M. Angiolini
F. Zuccotto
A. Bernardi
F. Airaghi

June 2016

The present invention relates to novel heterocyclic derivatives having general formula (I) and thei...

Biphenyl tricyclic quinazoline compounds

Chilin, Adriana
Marzaro, Giovanni
Guiotto, Adriano
Conconi, MARIA TERESA
Castagliuolo, Ignazio

January 2012

The invention is directed to certain novel compounds with biphenyl tricyclic quinazoline structure. ...

COMPOUNDS AND USES THEREOF

BOTTA, MAURIZIO
DREASSI, ELENA
TINTORI, CRISTINA
VIGNAROLI, GIULIA
Angelucci, Adriano
Schenone, Silvia

January 2016

The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

McIver, Edward G.
Bryans, Justin
Birchall, Kristian
Chugh, Jasveen
Drake, Thomas
Lewis, Stephen J.
Osborne, Joanne
Smiljanic-Hurley, Ela
Tsang, William
Kamal, Ahmad
Levy, Alison
Newman, Michelle
Taylor, Debra
Arthur, J. Simon C.
Clark, Kristopher
Cohen, Philip

December 2012

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclop...

Piperidine derivatives for use in the treatment of pancreatic cancer

Vogel, Pierre
Duchosal, Michel
Aimable, Nahimana
Inmaculada, Robina
Mollinedo, Faustino
Nencioni, Alessio

August 2016

The present invention relates to novel piperidine derivatives having better cell growth inhibitory a...

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

McIver, Edward G
Bryans, Justin
Birchall, Kristian
Chugh, Jasveen
Drake, Thomas
Lewis, Stephen J
Osborne, Joanne
Smiljanic-Hurley, Ela
Tsang, William
Kamal, Ahmad
Levy, Alison
Newman, Michelle
Taylor, Debra
Arthur, J Simon C
Clark, Kristopher
Cohen, Philip

September 2012

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclop...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Reuillon, Tristan
Miller, Duncan
Myers, Stephanie
Molyneux, Lauren
Cano, Céline
Hardcastle, Ian
Griffin, Roger
Rigoreau, Laurent
Golding, Bernard
Noble, Martin

March 2016

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Newton, G
Stewart, M

January 2012

Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases assoc...

COMPOUNDS AND THEIR USES

Newton, G
Lord, C

February 2013

The invention provides a compound that is an inhibitor of one or both of TBK1 and IKKe, or a down-re...

Kinase inhibitors

Fischer, Peter
Fromont, Christophe
Stevenson, Brett
Butterworth, Sam
Iacobini, Greg
Greco, Graziella
Sanz, Miguel Garzon
Jones, Heulyn
Kaur, Divneet

November 2019

The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...

Piperazinylpyrimidine analogues as protein kinase inhibitors

Russu, Wade A.
Shallal, Hassan M.

December 2013

The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as prot...

MAP4K4 Inhibitors

Newton, G
Schneider, M

April 2019

This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections

Greff, Zoltán
Varga, Zoltán
Kéri, György
Õrfi, László
Pató, János
Bánhegyi, Péter
Szántai-kis, Csaba
Cole, Stewart
Hartkoorn, Ruben
Székely, Rita Edina

May 2017

The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formul...

Heterocyclic derivatives modulating the activity of certain protein kinases

M. Angiolini
F. Zuccotto
A. Bernardi
F. Airaghi

June 2016

The present invention relates to novel heterocyclic derivatives having general formula (I) and thei...

Biphenyl tricyclic quinazoline compounds

Chilin, Adriana
Marzaro, Giovanni
Guiotto, Adriano
Conconi, MARIA TERESA
Castagliuolo, Ignazio

January 2012

The invention is directed to certain novel compounds with biphenyl tricyclic quinazoline structure. ...

COMPOUNDS AND USES THEREOF

BOTTA, MAURIZIO
DREASSI, ELENA
TINTORI, CRISTINA
VIGNAROLI, GIULIA
Angelucci, Adriano
Schenone, Silvia

January 2016

The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

McIver, Edward G.
Bryans, Justin
Birchall, Kristian
Chugh, Jasveen
Drake, Thomas
Lewis, Stephen J.
Osborne, Joanne
Smiljanic-Hurley, Ela
Tsang, William
Kamal, Ahmad
Levy, Alison
Newman, Michelle
Taylor, Debra
Arthur, J. Simon C.
Clark, Kristopher
Cohen, Philip

December 2012

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclop...

Piperidine derivatives for use in the treatment of pancreatic cancer

Vogel, Pierre
Duchosal, Michel
Aimable, Nahimana
Inmaculada, Robina
Mollinedo, Faustino
Nencioni, Alessio

August 2016

The present invention relates to novel piperidine derivatives having better cell growth inhibitory a...

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.

McIver, Edward G
Bryans, Justin
Birchall, Kristian
Chugh, Jasveen
Drake, Thomas
Lewis, Stephen J
Osborne, Joanne
Smiljanic-Hurley, Ela
Tsang, William
Kamal, Ahmad
Levy, Alison
Newman, Michelle
Taylor, Debra
Arthur, J Simon C
Clark, Kristopher
Cohen, Philip

September 2012

The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclop...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Reuillon, Tristan
Miller, Duncan
Myers, Stephanie
Molyneux, Lauren
Cano, Céline
Hardcastle, Ian
Griffin, Roger
Rigoreau, Laurent
Golding, Bernard
Noble, Martin

March 2016

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Abstract

Extracted data

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Abstract

Extracted data

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