Add to ORKGThis invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I)
(EN) The present invention relates to compounds of formula (I) and compositions comprising the same....
Studies have linked the serine-threonine kinase MAP4K4 to the regulation of a number of biological p...
We developed a pharmacophore model for type II inhibitors that was used to guide the construction of...
The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as prot...
The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formul...
Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases assoc...
The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...
The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...
The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
The present invention relates to novel heterocyclic derivatives having general formula (I) and thei...
The present invention refers to 4-\u200bamino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyr...
(EN) The present invention relates to compounds of formula (I) and compositions comprising the same....
Studies have linked the serine-threonine kinase MAP4K4 to the regulation of a number of biological p...
We developed a pharmacophore model for type II inhibitors that was used to guide the construction of...
The invention provides novel compounds based on piperazinylpyrimidine derivatives to be used as prot...
The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formul...
Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases assoc...
The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...
The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...
The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
The present invention relates to novel heterocyclic derivatives having general formula (I) and thei...
The present invention refers to 4-\u200bamino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyr...
(EN) The present invention relates to compounds of formula (I) and compositions comprising the same....
Studies have linked the serine-threonine kinase MAP4K4 to the regulation of a number of biological p...
We developed a pharmacophore model for type II inhibitors that was used to guide the construction of...