Recent progress in the total synthesis of naphthyridinomycin and lemonomycin tetrahydroisoquinoline antitumor antibiotics (TAAs)
- Siengalewicz, Peter (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
- Rinner, Uwe (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
- Mulzer, Johann (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)
Publication date
January 2008
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
0306-0012 Citation count (estimate)
60Abstract
In this tutorial review, which should be of general interest to synthetic organic chemists at large, recent progress in the total synthesis of the tetrahydroisoquinoline antitumor antibiotics cyanocycline A, naphthyridinomycin, bioxalomycin ?2, and lemonomycin is highlighted in detail and some biological background information is given as well. Preparations of truncated derivatives and uncompleted synthetic approaches are also described. The literature coverage includes the newest research results through the year 2008
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