Tailored antimicrobial activity and long-term cytocompatibility of plasma polymer silver nanocomposites

The deposition of coatings enabling antibacterial properties in combination with cytocompatibility remains a challenge for biomaterial applications, such as in medical devices. Silver is one of the most utilized antibacterial surface components, due to its efficacy and extensive applicability. In this work, silver-containing plasma polymer nanocomposites (single layer and multilayers) were developed and tested, with a focus on cytotoxicity and bactericidal function, on the NIH3T3 mammalian cell line as well as Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strains. The data demonstrate that a tuneable Ag+ release is required, allowing sufficient antimicrobial activity while retaining appropriate cytocompatibility over the entire testing period of up to eight days